GABAB receptors control neuronal excitability via slow and prolonged inhibition in the central nervous system.One important function of GABAB receptors under physiological condition is to prevent neurons from shifting into an overexcitation state which can lead to excitotoxic death.However, under ischemic conditions, GABAB receptors are downregulat
Biological Evidence Management for DNA Analysis in Cases of Sexual Assault
Biological evidence with forensic interest may be found in several cases of assault, being particularly relevant if sexually related.Sexual assault cases are characterized by low rates of disclosure, reporting, prosecution, and conviction.Biological evidence is sometimes the only way to prove the occurrence of sexual contact and to identify the per
Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction.
Interferon regulatory factor 8 (IRF8), also known as interferon consensus sequence-binding protein (ICSBP), is a transcription factor of the IRF family.IRF8 plays a key role in normal B cell differentiation, a cellular process that is intrinsically associated with Epstein-Barr virus (EBV) reactivation.However, whether IRF8 regulates EBV lytic repli